ENHANCED AND PROLONGED ANTITUMOR EFFECT OF SALINOMYCIN-LOADED GELATINASE-RESPONSIVE NANOPARTICLES VIA TARGETED DRUG DELIVERY AND INHIBITION OF CERVICAL CANCER STEM CELLS

Qin Wang,1,* Fangcen Liu,2,* Lifeng Wang,1 Chen Xie,3 Puyuan Wu,1 Shiyao Du,1 Shujuan Zhou,1 Zhichen Sun,1 Qin Liu,1 Lixia Yu,1 Baorui Liu,1 Rutian Li1 1The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, People’s Republic of China; 2The

Abstract Background Heart disease could result from a malfunction in the core clock gene BMAL1, according to studies conducted on animals and humans in vitro and in vivo.However, in pathological conditions, the role of BMAL1 was not clear.In the present study, we identified a potential link between BMAL1 and cardiac hypertrophy.Methods Primary cult

Incentivising has shown to improve participation in clinical trials.However, ethical concerns suggest that incentives may be coercive, obscure trial risks and encourage individuals to enrol in clinical trials for the girls tees wrong reasons.The aim of our study was to develop and pilot a discrete choice experiment (DCE) to explore and identify pre

In order to secure the safe operation of the ship, it is crucial to closely examine the suitability from the design stage of the ship, and to set up a preliminary review and countermeasures for failures and defects that may occur during the construction process.In shipyards, the failure mode and effects analysis (FMEA) evaluation method using risk

Abstract Background This is the first report of Besnoitia bennetti in donkeys in Ireland.B.bennetti, an apicomplexan protozoan parasite specific to equids, is an emerging pathogen in Europe.This parasite forms chronic intracytoplasmic cysts in cells of the mesenchymal lineage, mainly fibroblasts, in the skin, sclera and mucosa.Clinical signs in aff